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GENERIC NAME(S): Diazepam
Diazepam, first marketed as Valium, is a medicine of the benzodiazepine family that acts as an anxiolytic. It is commonly used to treat a range of conditions, including anxiety, seizures, alcohol withdrawal syndrome, muscle spasms, insomnia, and restless legs syndrome. It may also be used to cause memory loss during certain medical procedures. It can be taken by mouth, inserted into the rectum, injected into muscle, injected into a vein or used as a nasal spray. When given into a vein, effects begin in one to five minutes and last up to an hour. By mouth, effects begin after 15 to 60 minutes.
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Common side-effects include sleepiness and trouble with coordination. Serious side effects are rare. They include increased risk of suicide, decreased breathing, and an increased risk of seizures if used too frequently in those with epilepsy. Occasionally, excitement or agitation may occur. Long-term use can result in tolerance, dependence, and withdrawal symptoms on dose reduction. Abrupt stopping after long-term use can be potentially dangerous. After stopping, cognitive problems may persist for six months or longer. It is not recommended during pregnancy or breastfeeding. Its mechanism of action works by increasing the effect of the neurotransmitter gamma-aminobutyric acid (GABA).
Diazepam was patented in 1959 by Hoffmann-La Roche. It has been one of the most frequently prescribed medications in the world since its launch in 1963. In the United States it was the best-selling medication between 1968 and 1982, selling more than 2 billion tablets in 1978 alone. In 2020, it was the 128th most-commonly prescribed medication in the United States, with more than 4 million prescriptions. In 1985 the patent ended, and there are now more than 500 brands available on the market. It is on the World Health Organization's List of Essential Medicines.
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Diazepam is mainly used to treat anxiety, insomnia, panic attacks and symptoms of acute alcohol withdrawal. It is also used as a premedication for inducing sedation, anxiolysis, or amnesia before certain medical procedures (e.g., endoscopy). In 2020, it was approved for use in the United States as a nasal spray to interrupt seizure activity in people with epilepsy. Diazepam is the most commonly used benzodiazepine for "tapering" benzodiazepine dependence due to the drug's comparatively long half-life, allowing for more efficient dose reduction. Benzodiazepines have a relatively low toxicity in overdose.
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Diazepam has a number of uses, including:
Treatment of anxiety, panic attacks, and states of agitation
Treatment of neurovegetative symptoms associated with vertigo
Treatment of the symptoms of alcohol, opiate, and benzodiazepine withdrawal
Short-term treatment of insomnia
Treatment of muscle spasms
Treatment of tetanus, together with other measures of intensive treatment
Adjunctive treatment of spastic muscular paresis (paraplegia/tetraplegia) caused by cerebral or spinal cord conditions such as stroke, multiple sclerosis, or spinal cord injury (long-term treatment is coupled with other rehabilitative measures)
Palliative treatment of stiff person syndrome
Pre- or postoperative sedation, anxiolysis or amnesia (e.g., before endoscopic or surgical procedures)
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Treatment of complications with stimulant overdoses and psychosis, such as cocaine or methamphetamine
Used in treatment of organophosphate poisoning and reduces the risk of seizure induced brain and cardiac damage.
Preventive treatment of oxygen toxicity during hyperbaric oxygen therapy
Dosages should be determined on an individual basis, depending on the condition being treated, severity of symptoms, patient body weight, and any other conditions the person may have.
How does diazepam make you feel?
Diazepam belongs to a group of medicines called benzodiazepines. It works by increasing the levels of a calming chemical in your brain. Depending on your health condition, this can make you feel drowsy, relieve anxiety, stop seizures or relax tense muscles.
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How it works
Diazepam belongs to a class of drugs called benzodiazepines. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.
Diazepam increases the activity of gamma-aminobutyric acid (GABA), a special chemical that can send signals throughout your nervous system. If you don’t have enough GABA, your body may be in an excited state and cause you to have anxiety, get muscle spasms, or have seizures. When you take this drug, you’ll have more GABA in your body. This will help decrease your anxiety, muscle spasms, and seizures.
Diazepam side effects
Diazepam can cause mild or severe side effects.
Diazepam oral tablet can slow down your brain’s activity and interfere with your judgment, thinking, and motor skills. You shouldn’t drink alcohol or use other drugs that can also slow down your brain’s activity while you're
e taking diazepam. You also shouldn’t drive, operate machinery, or do other tasks that require alertness until you know how this drug affects you. There are additional effects that you should also be aware of.
The following list contains some of the key side effects that may occur while taking diazepam. This list does not include all possible side effects. For more information on the possible side effects of diazepam, or for tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.
More common side effects
The more common side effects that can occur with diazepam include:
tiredness or fatigue
inability to control muscle movements (ataxia)
dry mouth or excessive saliva
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
Worsening of seizures. Symptoms can include:
increase in frequency
increase in severity
Changes in the brain or how you think. Symptoms can include:
feelings of the room spinning (vertigo)
slowed or slurred speech
double or blurred vision
thoughts of suicide
Unexpected reactions. Symptoms can include:
increased muscle spasms
Liver problems. Symptoms can include:
yellowing of your skin or whites of your eyes (jaundice)
Bladder problems. Symptoms can include:
inability to urinate
inability to hold urine
Increase or decrease in sex drive.
Withdrawal. Symptoms can include:
abdominal or muscle cramps
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