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Alprazolam, sold under the brand name Xanax, among others, is a fast-acting, potent tranquilizer of medium duration in the triazolobenzodiazepine (TBZD) class, which are benzodiazepines (BZDs) fused with a triazole ring. It is most commonly used in the management of anxiety disorders, specifically panic disorder or generalized anxiety disorder (GAD) Other uses include the treatment of chemotherapy-induced nausea, together with other treatments GAD improvement occurs generally within a week. Alprazolam is generally taken by mouth. Common side effects include sleepiness, depression, headaches, feeling tired, dry mouth, and memory problems. Some of the sedation and tiredness may improve within a few days. Withdrawal or rebound symptoms may occur if use is suddenly decreased; gradually decreasing the dose over weeks or months may be required. Alprazolam increases all-cause mortality. Alprazolam, like other benzodiazepines, acts through the GABAA receptor.
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Alprazolam was invented by Dr. Jackson Hester at the Upjohn Company and patented in 1971 and approved for medical use in the United States in 1981. Alprazolam is a Schedule IV controlled substance and is a common drug of abuse. It is available as a generic medication. In 2020, it was the 37th most-commonly-prescribed medication in the United States, with more than 16 million prescriptions.
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Alprazolam pills in boxes, as sold in France. Both Xanax (original Pfizer alprazolam product) and various generic forms of alprazolam
Alprazolam is mostly used in management of anxiety disorders, panic disorders, and nausea due to chemotherapy. Alprazolam is indicated for the treatment of generalized anxiety disorder and panic disorder with or without agoraphobia in adults. The FDA label advises that the physician should periodically reassess the usefulness of the drug, Alprazolam is used to treat anxiety disorders and panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks). Alprazolam is in a class of medications called benzodiazepines. It works by decreasing abnormal excitement in the brain.
What does Xanax do?
Benzodiazepines like Xanax reduce anxiety by attaching to a receptor in your brain called the GABA-A (gamma-aminobutyric acid-A) receptor. When Xanax binds to this receptor, it has a calming effect in the brain. Xanax is often prescribed for anxiety disorders because it can help relieve anxiety symptoms quickly. However, other anxiety medications and talk therapy are better long-term choices for treating anxiety because Xanax has side effects, a risk of overdose, and the potential for dependence.
How long does it take Xanax to work?
For most patients, Xanax will start to work within one to two hours. These other treatments may take a few weeks to take effect, though. So Xanax and other benzodiazepines are sometimes used as a “bridge” until other treatments can have a chance to work.
What are some of the concerns of taking Xanax?
If you are taking Xanax, you should be aware of its side effects. Possible side effects include:
Weight loss or weight gain
Nausea or vomiting
Low blood pressure
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Some people should avoid Xanax because they may be more sensitive to its side effects or it might harm them. These groups include:
Children and teens
People who have misused alcohol or drugs
People with certain medical conditions such as respiratory illnesses
People who take Xanax should also be aware of the possibility of misusing or becoming dependent on it. Some people misuse Xanax because they like the way it makes them feel, which can lead to inappropriate use or overuse. When someone needs higher or more frequent doses of the medication to achieve the same effect, this is known as tolerance.
Building a tolerance to Xanax or other benzodiazepines can lead to dependence. A dependence means your body begins to rely on Xanax to function normally, and you can experience serious withdrawal symptoms if you stop taking it suddenly.
Certain people are at greater risk for misusing Xanax, including:
Young adults 18 to 35 years old
Someone who has a current psychiatric disorder
Someone with a personal or family history of substance abuse
What is the safest way to take Xanax?
Because of Xanax’s serious side effects and the risk of misuse and dependence, you should only take it under the supervision of a healthcare provider. If you and your provider decide that Xanax is right for you, take it at the lowest dose possible for the shortest time possible.
If you are taking Xanax, you should also avoid alcohol and certain drugs such as opioids (Vicodin, Oxycontin). These substances affect the brain in similar ways and can have an additive effect. They can lead to serious health complications such as breathing problems and sometimes even death. All of these substances have a high risk of misuse and dependence.
You might be taking other medications in addition to Xanax or another benzodiazepine. Certain medications, when taken with Xanax, can slow down or speed up the amount of time it takes Xanax to leave the body. Conversely, sometimes Xanax can slow down or speed up how long it takes other medications to leave the body.
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